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Use rosuvastatin with caution in ASIAN patients and in the ELDERLY; they may be more sensitive to its effects, especially serious muscle problems eg, muscle pain, tenderness, or weakness. Khan, A. Diabetes Care, December 2003; vol 2612: pp 3215-3218. Kasture, S. Effect of pomegranate juice on Angiotensin II-induced hypertension in diabetic Wistar rats. Phytother. Pande, G. and Akoh, C. C. Antioxidant capacity and lipid characterization of six Georgia-grown pomegranate cultivars.

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So even though studies have shown that RYRE can lower cholesterol, you can't really know if the supplement brand you're using will have that effect. What Are the Risks of Red Yeast Rice? Poursafa, P. Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome. R” on one side and “5” on the other side.

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Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study. Int J Impot. Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in clinical practice. In rare cases, Livalo can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

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Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Should not be used in patients with these conditions. In essence, what I am saying is that this is the most comprehensive evidence-based unbiased assessment of all these drugs and the guidelines should be followed by all physicians and their patients.



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This information is generalized and not intended as specific medical advice. Avert: “Antiretroviral Side Effects. Kotyla, P. The Journal of Rheumatology, April 2006; vol 334: p 827. Early research shows that drinking pomegranate juice daily for 4 weeks does not improve erectile dysfunction in men. Hepatic ImpairmentIn patients with chronic alcohol liver disease, plasma concentrations of rosuvastatin were modestly increased. Tell your doctor all medications and supplements you use. Rosuvastatin calcium is not recommended for use during pregnancy; it may harm a fetus. Females should talk to their doctor about using contraceptives while taking rosuvastatin calcium. Rosuvastatin calcium passes into breast milk. Because of the possibility of unwanted effects on a nursing infant, breastfeeding while using rosuvastatin calcium is not recommended. Jing, X. HuanRong D. and Gong Y. Effect of pomegranate juice and apple juice on free radical metabolism in liver, heart and brain of aged rats.



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After 18 months of treatment, researchers found those who received the higher dose had greater reductions in "bad" than those who received the lower dose. Some medications for high blood pressure include captopril Capoten enalapril Vasotec lisinopril Prinivil, Zestril ramipril Altace and others. Four panels were assembled which focused on the muscle, liver, renal, and neurological effects of statins. El-Benna, J. An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice. Food Chem. No effects on sexual development, testicular and epididymal appearance or fertility were observed at either dose level. Ask your pharmacist for a list of the ingredients. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Chandu, G. N. Fluoride content in bottled drinking waters, carbonated soft drinks and fruit juices in Davangere city, India. Martins-Green, M. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. Integr. Benherlal, P. S. and Arumughan, C. Studies on modulation of DNA integrity in Fenton's system by phytochemicals. Mutat. prograf



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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Scull, R. Screening of medicinal plants against Leishmania amazonensis. Pharm. Imaging tests, like X-rays, CT scans, ultrasounds, and MRI. These look inside your body for tumors or other signs that cancer has spread. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Warnings: Pregnancy and breast-feeding: Pomegranate juice is POSSIBLY SAFE for pregnant and breast-feeding women. However there is not enough reliable information about the safety of using other forms of pomegranate, such as pomegranate extract. If you use pomegranate, stick with the juice during pregnancy or breast-feeding. Check with your healthcare provider first. Low blood pressure: Drinking pomegranate juice can slightly lower blood pressure. Drinking pomegranate juice might increase the risk of blood pressure dropping too low in people who already have low blood pressure. Allergies to plants: People with plant allergies seem to be more likely to have an allergic reaction to pomegranate. Surgery: Pomegranate might affect blood pressure. This might interfere with blood pressure control during and after surgery. Stop taking pomegranate at least 2 weeks before a scheduled surgery. If you miss a dose of rosuvastatin calcium tablets, take it as soon as you remember. However, do not take 2 doses of rosuvastatin calcium tablets within 12 hours of each other. Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice PJ consumption by diabetic patients on serum and on macrophages. Tell your doctor if you have any side effect that bothers you or that does not go away. This is given by injection into a muscle or vein as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. Drink plenty of fluids while using this medication unless your doctor directs you otherwise. Zhang, L. H. Li L. L. Li Y. X. and Zhang Y. H. In vitro antioxidant activities of fruits and leaves of Pomegranate. This medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. Some research suggests that men who are exposed to certain strains of HPV human papillomavirus may also be more likely to get penile cancer. The dosage is based on your medical condition, response to treatment, age, race, and other you may be taking. Qu, W. Pan Z. L. and Ma H. Extraction modeling and activities of antioxidants from pomegranate marc. Tell your doctor if you are before using this medication. Dr. Ishak Mansi, from the VA North Texas System in Dallas.



Does rosuvastatin interact with other medications

Keep in mind that the amount of monacolin -- perhaps the most important ingredient -- in a red yeast rice extract can vary a lot. There are many different strains of the yeast. Different types of fermentation are used. Haidari M, Ali M, Ward Casscells S 3rd, Madjid M. Pomegranate Punica granatum purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir. Gemfibrozil significantly increased rosuvastatin exposure. Because red yeast rice extract contains a substance classified as a prescription drug, the FDA has attempted to control its sale. El Nemr SE, Ismail IA, and Ragab M. The chemical composition of the juice and seeds of pomegranate fruits. generic bupropion purchase uk



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Ahmad, I. Broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum L. peel extracts. Mutat. Tell your doctor if your condition lasts or gets worse. It may take up to 4 weeks before you get the full benefit of this drug. Included as part of the PRECAUTIONS section. Kwon, D. Y. In Vitro and In Vivo Antibacterial Activity of Punica granatum Peel Ethanol Extract against Salmonella. Evid. Abrams, J. Journal of Lipid Research, 1981; vol 2: pp 307-322. Lacroix, A. Z. The Herbal Alternatives for Menopause HALT Study: background and study design. The usual starting dose is 10 to 20 mg once daily. The usual starting dose in adult patients with homozygous familial hypercholesterolemia is 20 mg once daily. Patients should be advised to report promptly unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever or if these muscle signs or symptoms persist after discontinuing rosuvastatin calcium tablets. Haqqi, T. M. Polyphenol-rich pomegranate fruit extract POMx suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kappaB in human KU812 cells. Bottles of 120: NDC 0173-0884-08. C and in a dry place. Limited published data on rosuvastatin have not shown an increased risk of major congenital malformations or miscarriage. Rare reports of congenital anomalies have been received following intrauterine exposure to other statins. Santos, J. E. Effects of feeding polyphenols from pomegranate extract on health, growth, nutrient digestion, and immunocompetence of calves. National Institute on Aging: “Hormones and Menopause.



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Rosuvastatin is usually taken once a day, with or without food. Take the medicine at the same time each day. Sudathip, S. Pharmacological Research, August 2011; vol 642: pp 146-154. Some medications are changed and broken down by the liver. Pomegranate might decrease how quickly the liver breaks down some medications. Taking pomegranate along with some medications that are changed by the liver can increase the effects and side effects of your medication. Before taking pomegranate talk to your healthcare provider if you take any medications that are changed by the liver. If you miss a dose of rosuvastatin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or within 12 hours of each other. Follow your doctor's directions carefully. If you are of Asian descent or if you have problems, your doctor may direct you to start with a lower dose because you may be more sensitive to its effects. Rosuvastatin calcium tablets significantly increasedINR in patients receiving coumarin anticoagulants. Therefore, caution should beexercised when coumarin anticoagulants are given in conjunction with rosuvastatincalcium tablets. Continue to take rosuvastatin even if you feel well. Do not miss any doses. Keep using this medicine as directed, even if you feel well. High cholesterol usually has no symptoms. You may need to take rosuvastatin on a long-term basis. In vivo studies in animals, and in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for cholesterol lowering. In in vivo and in vitro studies, rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of VLDL, which reduces the total number of VLDL and LDL particles. Ozawa, T. Extensive screening for herbal extracts with potent antioxidant properties. It is recommended that liver enzyme tests be performed before the initiation of rosuvastatin calcium tablets and if signs or symptoms of liver injury occur. All patients treated with rosuvastatin calcium tablets should be advised to promptly report any symptoms that may indicate liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine or jaundice. aygestin price in new york



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In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Namdar, R. Antioxidant properties of peel and pulp hydro extract in ten Persian pomegranate cultivars. Pak. This list is not complete. Other drugs may interact with pitavastatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Talk to your doctor or about lifestyle changes that might benefit you. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Zhu, J. Yu L. Zhang L. Cui X. Ai H. Effect of water extraction from pomegranate peel on cardiac electrical activity of Bufo Bufo Gargarizans in vivo. Langley P. Why a pomegranate? Kelebek, H. and Canbas A. Organic acid, sugar and phenolic compounds and antioxidant capacity of Hicaz pomegranate juice. Tu, H. Liu D. and Xiong X. Y. Oil extract from pomegranate seed and its composition analysis. LOVAZA capsules before swallowing. Gedikli, O. Antioxidant effect of pomegranate extract in reducing acute inflammation due to myringotomy. Rattanachaikunsopon, P. and Phumkhachorn, P. Use of asiatic pennywort Centella asiatica aqueous extract as a bath treatment to control columnaris in Nile tilapia. Medicines like rosuvastatin calcium tablets can pass into your breast milk and may harm your baby. Borah, A. Anti-oxidant effect of extracts of kinnow rind, pomegranate rind and seed powders in cooked goat meat patties. Meat. In contrast, the volume of plaque buildup increased by nearly 3% during treatment among those taking the lower-dose therapy.



Food Chem 11-10-2010; View abstract

Parashar, A. Gupta C. Gupta S. K. and Kumar A. Antimicrobial ellagitannin from pomegranate Punica granatum fruits. Pantuck AJ, Zomorodian N, Belldegrun AS. Phase-II Study of pomegranate juice for men with prostate cancer and increasing PSA. Kaplan M, Hayek T, Raz A, et al. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. If these rare effects occur, talk to your doctor. CHD have achieved recommended goal levels of LDL cholesterol. Rosuvastatin calcium tablets may harm your unborn baby. If you become pregnant, stop taking rosuvastatin calcium tablets and call your doctor right away. Obesity. Early research suggests that taking a specific combination product Xanthigen containing pomegranate seed oil and brown marine algae reduces body weight in obese women with liver disease. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. In this study, researchers compared the effects of intensive statin therapy using 80 mg daily of vs. a more moderate approach using 40 mg of in more than 500 adults with atherosclerosis. Hadipour-Jahromy, M. and Mozaffari-Kermani, R. Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice. Phytother. Myalgia was the most common adverse reaction that led to treatment discontinuation. At first, 20 milligrams mg once a day. Your doctor may adjust your dose as needed. Ajaikumar KB, Asheef M, Babu BH, Padikkala J. The inhibition of gastric mucosal injury by Punicagranatum L. pomegranate methanolic extract. Gangemi S, Mistrello G, Roncarolo D, et al. Pomegranate-dependent exercise-induced anaphylaxis. Women who may become pregnant should use effective birth control while taking rosuvastatin. Check with your doctor if you have questions about using birth control. valtrex



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Babich, H. Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells. Anticancer Agents Med. Fuhrman, B. Paraoxonase 1 PON1 expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway. Rosuvastatin is to be used only by the patient for whom it is prescribed. Do not share it with other people. ALT and AST and your bad cholesterol levels -C. Hardening of the arteries atherosclerosis. Early research suggests that drinking pomegranate juice might help to keep the arteries in the neck carotid arteries clear of the build-up of fatty deposits. Yoshikawa, M. Medicinal flowers. XXIII. New taraxastane-type triterpene, punicanolic acid, with tumor necrosis factor-alpha inhibitory activity from the flowers of Punica granatum. Chem. Naughton, D. P. Antimicrobial pomegranate rind extracts: enhancement by CuII and vitamin C combinations against clinical isolates of Pseudomonas aeruginosa. This drug may rarely cause muscle problems which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy. You should not become pregnant while you are taking rosuvastatin. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking rosuvastatin, call your doctor immediately. Rosuvastatin may harm the fetus. Ratlarda periferal kan hücreleri üzerine L-karnitin, ar sütü ve nar cekirdeginin etkileri. Kafkas Üniversitesi.



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Check your regularly while taking this medication. Learn how to monitor your own pressure, and share the results with your doctor. Limited published data on the use of rosuvastatin are insufficient to determine a drug-associated risk of major congenital malformations or miscarriage. Longtin R. The pomegranate: nature's power fruit? Albrecht M, Jiang W, Kumi-Diaka J, et al. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. Heber, D. Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int. Keep rosuvastatin calcium tablets and all medicines out of the reach of children. canada zantac venezuela



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Benzer, F. Kandemir F. M. Yildirim N. C. and Ozan S. T. Effect of pomegranate seed extract on free radical damage and antioxidant activity under cisplatin-induced oxidative stress conditions in rabbit testes. Is Red Yeast Rice Extract a Drug or a Supplement? Side effects from prescription lovastatin include elevation of and muscle enzymes, muscle problems, and liver problems. How should I take LOVAZA? They found that people taking statins had a 19 percent greater risk of having musculoskeletal problems compared with nonusers. Specifically, statin users were 13 percent more likely to suffer dislocations, strains or sprains.



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HbA1c and fasting serum levels. Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Mousavinejad, G. Emam-Djomeh Z. Rezaei K. and Khodaparast M. H. H. Identification and quantification of phenolic compounds and their effects on antioxidant activity in pomegranate juices of eight Iranian cultivars. Rosuvastatin clearance is not dependent on metabolism by cytochrome P450 3A4 to a clinically significant extent. There is no specific treatment in the event of overdose. In the event of overdose, the patient should be treated symptomatically and supportive measures instituted as required. Hemodialysis does not significantly enhance clearance of rosuvastatin. Avoid using antacids without your doctor's advice. Use only the type of antacid your doctor recommends, and do not take it within 2 hours after taking rosuvastatin. Some antacids can make it harder for your body to absorb rosuvastatin. Martin, K. R. Krueger C. G. Rodriquez G. Dreher M. and Reed J. D. Development of a novel pomegranate standard and new method for the quantitative measurement of pomegranate polyphenols. Hamdi, M. Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds. Phytomedicine. An extra patient leaflet is available with rosuvastatin. Talk to your pharmacist if you have questions about this information. It works by stopping the growth of bacteria. Koski, R. Pharmacy and Therapeutics, May 2008; vol 335: pp 271-303. June 2012; vol 873. And if they do shrink the risk, the effect seems to be small. opad.info ciprofloxacin



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It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps to prevent strokes and heart attacks. Gharzouli, A. Effects of Quercus ilex L. and Punica granatum L. polyphenols against ethanol-induced gastric damage in rats. Antacids containing aluminum or can reduce the absorption of this drug. Therefore, if taking this type of antacid, take it at least 2 hours after this medication. Alcohol can increase the risk of serious side effects.

Prescribing information for rosuvastatin

High cholesterol hyperlipidemia. Some studies show that pomegranate juice can lower total cholesterol and “bad” LDL cholesterol. However, other studies find no benefit. Pomegranate seed oil, but not pomegranate juice, may improve triglycerides and “good” HDL cholesterol levels. Do not stop or change your dose without checking first with your doctor, even if you are feeling well. LDL apheresis What other drugs will affect rosuvastatin?

Rosuvastatin ingredients

Although this medication increases platelets and decreases the risk of bleeding, continue to avoid activities that can increase your risk of bleeding such as contact sports, using sharp objects like razors and nail cutters. Initiate rosuvastatin calcium tablets therapy with 5 mg once daily. Swallow the tablet whole. Do not break, crush, or chew it. You may take rosuvastatin with or without food. GenderThere were no differences in plasma concentrations of rosuvastatin between men and women. Keep out of the reach of children.

General information about rosuvastatin

For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. Sangster, M. Y. Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins. Antiviral Res. Do not breast-feed while you are taking Livalo.

LDL apheresis. This isn't a drug. It's a blood-cleansing procedure that may help with severe, genetic cholesterol disorders. Over several hours, blood is removed from the body, chemically cleansed of LDL cholesterol, and then returned to the body. Ferreira, D. Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay. If your symptoms do not improve or if they become worse, check with your doctor. HemodialysisSteady-state plasma concentrations of rosuvastatin in patients on chronic hemodialysis were approximately 50% greater compared with healthy volunteer subjects with normal renal function.

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